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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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Metabolic syndrome and cardiovascular risk in primary hypertension

Elena Ratto1, Giovanna Leoncini, Francesca Viazzi

  • 1Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.

Journal of the American Society of Nephrology : JASN
|March 28, 2006
PubMed

Insights

Metabolic syndrome is common in primary hypertension patients without diabetes, increasing cardiovascular and renal risks. Drug choice is crucial, favoring renin-angiotensin system inhibitors and calcium channel blockers.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Metabolic syndrome affects one-third of patients with primary hypertension but no diabetes.
  • It is linked to numerous cardiovascular risk factors and early cardiovascular/renal damage.
  • Metabolic syndrome is a predictor of increased cardiovascular events and mortality.

Purpose of the Study:

  • To highlight the significance of metabolic syndrome in hypertensive patients.
  • To emphasize the impact of antihypertensive drugs on metabolic syndrome.
  • To guide drug selection in patients with insulin resistance.

Main Methods:

  • Review of existing literature on metabolic syndrome and hypertension.
  • Analysis of cardiovascular risk factors associated with metabolic syndrome.
  • Evaluation of metabolic side effects of different antihypertensive drug classes.

Main Results:

  • Metabolic syndrome is prevalent in hypertensive individuals without diabetes.
  • Association with diverse cardiovascular and renal risk factors is confirmed.
  • Metabolic syndrome independently predicts adverse cardiovascular outcomes.

Conclusions:

  • Hypertensive patients with metabolic syndrome face elevated cardiovascular and renal risks.
  • Antihypertensive medication choice impacts metabolic profiles.
  • Renin-angiotensin system inhibitors and calcium channel blockers are preferred over beta blockers and diuretics in this population.

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