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Pituicytoma. Two case reports.

Yoko Nakasu1, Satoshi Nakasu, Akira Saito

  • 1Division of Neurosurgery, Shizuoka Cancer Center, Shizuoka. y.nakasu@scchr.jp

Neurologia Medico-Chirurgica
|March 28, 2006
PubMed
Summary

Pituicytoma, a rare glial neoplasm, presents in the sellar region. These tumors exhibit slow growth and typically do not require adjuvant therapy post-surgery.

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Area of Science:

  • Neuro-oncology
  • Endocrinology

Background:

  • Pituicytoma is a rare glial neoplasm originating in the sellar/suprasellar region.
  • Characterized by distinct histological features, it affects adults and has low proliferative activity.

Observation:

  • Two adult female patients presented with amenorrhea, vertigo, headache, mild hyperprolactinemia, and anterior pituitary dysfunction.
  • Suprasellar tumors were surgically resected and histologically identified as pituicytomas.

Findings:

  • Histological analysis revealed a storiform pattern with S-100 protein and glial fibrillary acidic protein immunoreactivity.
  • Ultrastructural studies showed intermediate filaments and basal lamina, but no cell-to-cell desmosomes.
  • Residual tumors showed no growth without adjuvant therapy over 18-56 months.

Implications:

  • Pituicytomas are noninfiltrative gliomas with a generally favorable prognosis.
  • Further research is needed to clarify the long-term prognosis and the role of adjuvant therapies.

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