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Related Experiment Videos

[Nutritional therapy in inflammatory bowel disease].

Marie-Astrid Piquet1, Romain Gloro, Anne-Marie Justum

  • 1Service d'Hépato-Gastroentérologie et Nutrition, Centre Hospitalier Universitaire de Caen, Avenue de la Côte de Nacre, 14033 Caen Cedex.

Gastroenterologie Clinique Et Biologique
|March 28, 2006
PubMed
Summary

Protein-energy malnutrition is frequent in inflammatory bowel diseases (IBD). While specific nutrients show promise, probiotics are a potential treatment for refractory pouchitis, warranting further clinical evaluation.

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Area of Science:

  • Gastroenterology
  • Nutritional Science
  • Immunology

Context:

  • Inflammatory bowel diseases (IBD), including Crohn's disease, are frequently associated with malnutrition and nutrient deficiencies.
  • Artificial nutrition is a critical intervention for adults with malnutrition, short bowel syndrome, or treatment-refractory IBD.
  • Enteral nutrition serves as a primary treatment in children with IBD to mitigate corticosteroid-induced growth impairment.

Purpose:

  • To explore the role of nutritional interventions and specific nutrients in managing inflammatory bowel diseases.
  • To evaluate the therapeutic potential of various nutrients, including n-3 fatty acids, glutamine, antioxidants, and probiotics, in IBD.
  • To assess the efficacy of probiotics as a treatment for refractory pouchitis.

Summary:

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  • Protein-energy malnutrition and specific nutrient deficiencies are prevalent in IBD, particularly Crohn's disease.
  • Nutritional support, including artificial and enteral nutrition, plays a vital role in managing IBD in both adults and children.
  • While several specific nutrients show pathophysiological promise, their clinical application requires further validation, with probiotics emerging as a promising option for refractory pouchitis.

Impact:

  • Highlights the significance of nutritional status in IBD management and treatment strategies.
  • Identifies potential therapeutic avenues through specific nutrient supplementation and probiotics.
  • Suggests a promising role for probiotics in managing refractory pouchitis, a challenging complication of IBD surgery.