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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Demineralized bone matrix and hydroxyapatite/tri-calcium phosphate mixture for bone healing in rats
Ali Oztürk1, H Yetkin, L Memis
1Department of Orthopaedics and Traumatology, Gazi University, Faculty of Medicine, Ankara, Turkey.
International Orthopaedics
|March 28, 2006
Summary
Demineralised bone matrix (DBM) alone enhanced bone healing in rat radius defects. Combining DBM with hydroxyapatite/tri-calcium phosphate (HA/TCP) did not improve results and potentially inhibited DBM
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Regenerative Medicine
Background:
- Hydroxyapatite/tri-calcium phosphate (HA/TCP) is an osteoconductive bone graft substitute.
- Demineralised bone matrix (DBM) is an osteoinductive material.
- Combining these materials may create a composite with both osteoconductive and osteoinductive properties.
Purpose of the Study:
- To evaluate the efficacy of a combined demineralised bone matrix (DBM) and hydroxyapatite/tri-calcium phosphate (HA/TCP) mixture in promoting bone healing.
- To assess the effect of this composite material on rat radius segmental defects.
Main Methods:
- Adult male Wistar rats underwent bilateral radial defect creation.
- Defects were treated with DBM, HA/TCP mixture, a combination of both, or left unfilled (control).
- Radiographic and histopathological analyses were performed 10 weeks post-implantation.
Main Results:
- Demineralised bone matrix (DBM) alone significantly improved bone healing compared to all other groups and the control.
- No significant differences in healing were observed between the HA/TCP mixture group, the combined DBM/HA/TCP group, and the control group.
Conclusions:
- Demineralised bone matrix (DBM) demonstrated superior bone healing properties when used alone.
- The combination of DBM and HA/TCP did not enhance bone healing and may inhibit the osteoinductive capacity of DBM.
