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Interleukin-12 in acute ischemic stroke patients.

Jarosław Zaremba1, Jacek Losy

  • 1Department of Clinical Neuroimmunology, Chair of Neurology, University School of Medicine, 49 Przybyszewskiego St, 60-355 Poznan, Poland.

Folia Neuropathologica
|March 28, 2006
PubMed
Summary

Elevated serum levels of interleukin-12 (IL-12) were observed in acute ischemic stroke patients compared to controls. These IL-12 levels correlated with stroke severity and inflammatory markers, suggesting a role in ischemic stroke.

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Area of Science:

  • Neuroscience
  • Immunology
  • Inflammation Research

Background:

  • Cytokines mediate stroke-induced inflammation, impacting infarct progression, disease severity, and outcomes.
  • Interleukin-12 (IL-12) is a key proinflammatory and immunomodulatory cytokine.

Purpose of the Study:

  • To evaluate serum IL-12 levels in acute ischemic stroke patients.
  • To investigate the relationship between IL-12 levels and demographic, laboratory, neuroimaging, and clinical data.

Main Methods:

  • Serum IL-12, erythrocyte sedimentation rate (ESR), and leukocyte count were measured in 23 ischemic stroke patients and 15 controls within 24 hours of stroke onset.
  • Cranial CT scans were performed to assess brain infarct volume.
  • Neurological and functional deficits were evaluated using the Scandinavian Stroke Scale (SSS) and Barthel Index (BI).

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Main Results:

  • Stroke patients exhibited significantly higher serum IL-12 levels than controls.
  • Serum IL-12 levels positively correlated with ESR values and the volume of hypodense areas on CT.
  • IL-12 levels showed significant correlations with SSS and BI scores at both initial assessment and two-week follow-up.

Conclusions:

  • The findings suggest that IL-12 may play a role in the pathophysiology of ischemic stroke.
  • Elevated IL-12 levels are associated with stroke severity and inflammatory markers.
  • Further research into IL-12's role could inform therapeutic strategies for ischemic stroke.