Related Experiment Video
Updated: Aug 9, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
Published on: July 4, 2007
[Mathematical model in prediction and evaluation of the effects on control measures for schistosomiasis]
1National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. ks_wu@163.com
Objective:
To carry out a theoretical research on the rule that a mathematical model may play on predicting and evaluating the control effect of schistosomiasis japonica.
Methods:
Earbour's two-host model was used to predict and evaluate the effect of different control measures by computer simulation. Pilot samples in two villages of Shanghai suburb in 1950s were applied for the analysis.
Results:
When the prevalence was high, synchronous chemotherapy for human and cattle populations quickly reduced the indices of the infection. Mollusciciding provided positive impact on the effect of chemotherapy. Added with the environmental measures for snail control, the basic reproductive rate (BRR) and equilibrium prevalence in human and bovines were sustainably reduced and even reached an interruption of transmission. The effect of chemotherapy could be consolidated by the anti-fecundity vaccine for bovines. Satisfied control effect could also be obtained by chemotherapy in human and bovines combined with behaviour intervention for human and vaccination for bovines without snail control. In areas with lower levels of transmission velocity, BRR and prevalence, the effect of various interventions was better than that obtained in areas with higher levels of the above three infection indices, and the disease control could be easier. Conclusion The Barbour's mathematical model can be used to roughly predict and evaluate the effects of schistosomiasis control measures.
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Malaria
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Typical Model Studies
Pharmacodynamic Models: Overview

