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Diagnostics for TSE agents.

A J Raeber¹, B Oesch

¹Prionics AG, Schlieren, Switzerland. alex.raeber@prionics.ch

Developments in Biologicals

|March 29, 2006

Summary

This summary is machine-generated.

Bovine Spongiform Encephalopathy (BSE) is a fatal neurodegenerative disease in cattle. Rapid diagnostic tests have improved BSE detection in cattle, but no tests exist for live animals or humans.

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Area of Science:

Veterinary Neurology
Food Safety
Prion Disease Research

Background:

Bovine Spongiform Encephalopathy (BSE), a fatal neurodegenerative disease in cattle, belongs to the transmissible spongiform encephalopathies (TSEs) or prion diseases.
BSE poses public health risks, as the agent can cause variant Creutzfeldt Jakob Disease (vCJD) in humans.
The first recognition of BSE in the U.K. in 1986 prompted significant public health concerns.

Purpose of the Study:

To address the high priority need for rapid diagnostic tests for BSE monitoring in cattle.
To enhance the detection of infected cattle before entering the human food chain.

Main Methods:

Implementation of mandatory active surveillance programs in the European Union.
Evaluation and approval of rapid screening tests for BSE detection in cattle.

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Main Results:

The European Union has approved twelve rapid tests for BSE monitoring.
Approval for two additional tests evaluated in 2004 is pending.
Rapid screening tests have significantly improved the detection of BSE-infected cattle.

Conclusions:

Current rapid tests are effective for active surveillance of BSE in cattle.
No diagnostic test is currently available for detecting prions in live animals or humans.
Research is ongoing to develop more sensitive and specific diagnostic techniques for prion detection in body fluids and identify novel surrogate markers.