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Updated: Aug 9, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
Published on: August 9, 2019
Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human
Josep Ramon Goñi1, Juan Manuel Vaquerizas, Joaquin Dopazo
1Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomèdica, Parc Científic de Barcelona, Josep Samitier 1-5, Barcelona 08028, Spain. rgoni@mmb.pcb.ub.es
Background:
DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions.
Results:
Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome.
Conclusion:
Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.
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