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Differentiated hemodynamic changes controlled by splanchnic nerve.

Monica Akemi Sato1, Shaun F Morrison, Oswaldo Ubriaco Lopes

  • 1Department of Physiology, Faculdade de Medicina do ABC, Av. Principe de Gales, 821, Vila Príncipe de Gales, 09060-650 Santo Andre, SP, Brazil. akemi@fcr.epm.br

Autonomic Neuroscience : Basic & Clinical
|March 29, 2006
PubMed
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The splanchnic nerve regulates blood pressure. Its electrical stimulation causes mesenteric vasoconstriction and hindquarter vasodilation via nitric oxide, suggesting dual tonic control over different vascular beds.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation
  • Vascular Biology

Background:

  • The splanchnic nerve plays a role in cardiovascular regulation.
  • Vasodilatory responses were thought to be due to reduced vasoconstrictor tone.

Purpose of the Study:

  • To investigate if different sympathetic nerves control vasodilatory and vasoconstrictor effects in distinct vascular beds.
  • To determine the hemodynamic changes in hindquarter, mesenteric, and renal vascular beds upon splanchnic nerve stimulation.

Main Methods:

  • Electrical stimulation of the splanchnic nerve in anesthetized rats.
  • Administration of L-NAME to assess nitric oxide involvement.
  • Sectioning of splanchnic nerves to evaluate tonic activity.

Related Experiment Videos

Main Results:

  • Splanchnic nerve stimulation caused hindquarter vasodilation and mesenteric/renal vasoconstriction.
  • L-NAME abolished hindquarter vasodilation, indicating nitric oxide mediation.
  • Bilateral splanchnic nerve section reduced hindquarter conductance.

Conclusions:

  • Splanchnic nerve stimulation induces mesenteric vasoconstriction and hindquarter vasodilation mediated by nitric oxide.
  • Splanchnic nerves may exert tonic vasodilation in the hindquarters and vasoconstriction elsewhere.