Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemically induced seizures.

Brandon Wills1, Timothy Erickson

  • 1University of Washington, Seattle, WA, USA. bkwills@gmail.com

Clinics in Laboratory Medicine
|March 29, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15-Year Retrospective Study from the Largest Children's Hospital in the United States.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

High Levels of Substance Use Disorder Among Critically Ill Virginia Medicaid Beneficiaries.

Journal of addiction medicine·2026
Same author

Converting Oral to Intravenous Methadone in a Hospitalized Patient With Opioid Use Disorder: A Case Report.

American journal of therapeutics·2025
Same author

Butorphanol-induced Precipitated Opioid Withdrawal With Stress Cardiomyopathy in the Setting of Chronic Fentanyl Use.

Journal of addiction medicine·2025
Same author

Designing, implementing and evaluating multidisciplinary healthcare training programmes in the wartime humanitarian context of Ukraine.

Emergency medicine journal : EMJ·2025
Same author

Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish <i>vps4a</i> Mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

Drug- and toxin-associated seizures (DTS) are often manageable with supportive care and benzodiazepines. Phenytoin may be harmful for managing DTS, highlighting the need for specific treatment approaches.

Area of Science:

  • Neuroscience
  • Toxicology
  • Pharmacology

Background:

  • Drug- and toxin-associated seizures (DTS) represent a significant clinical challenge.
  • A diverse range of agents can precipitate seizures, necessitating a broad understanding of potential causes.

Purpose of the Study:

  • To elucidate the pathophysiology of drug- and toxin-associated seizures.
  • To outline differential diagnoses and clinical presentations of DTS.
  • To review causative agents and provide management strategies for patients with DTS.

Main Methods:

  • Literature review of agents causing seizures.
  • Discussion of pathophysiology and clinical presentation.
  • Overview of management principles for DTS.

Related Experiment Videos

Main Results:

  • Most DTS cases are manageable with supportive care.
  • Benzodiazepines are recommended as first-line anticonvulsant therapy for DTS, except when specific antidotes are required.
  • Phenytoin is generally ineffective and potentially harmful in managing DTS.

Conclusions:

  • Understanding the pathophysiology and differential diagnosis is crucial for managing DTS.
  • Benzodiazepines are the preferred initial treatment for DTS.
  • Clinicians should be aware of agents that may be harmful, such as phenytoin, when treating DTS.