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Estrogen receptor testing of breast cancer in current clinical practice: what's the question?

Stuart J Schnitt1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|March 29, 2006
PubMed
Abstract

No abstract available in PubMed .

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: