Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polycomb silencing mechanisms and genomic programming.

V Pirrotta1

  • 1Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. pirrotta@biology.rutgers.edu

Ernst Schering Research Foundation Workshop
|March 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].

Genetika·2011
Same author

Functional dissection of the Suppressor of UnderReplication protein of Drosophila melanogaster: identification of domains influencing chromosome binding and DNA replication.

Genetica·2005
Same author

Polycomb silencing mechanisms in Drosophila.

Cold Spring Harbor symposia on quantitative biology·2005
Same author

Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes.

Chromosoma·2003
Same author

The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes.

Genetics·2002
Same author

Establishment of Polycomb silencing requires a transient interaction between PC and ESC.

Genes & development·2001
Same journal

Stem cells in reproduction and in the brain. Proceedings of a workshop. September 1-3, 2005. Kobe, Japan.

Ernst Schering Research Foundation workshop·2007
Same journal

Can cell systems biology rescue drug discovery?

Ernst Schering Research Foundation workshop·2007
Same journal

Applying a causal framework to system modeling.

Ernst Schering Research Foundation workshop·2007
Same journal

A plea for more theory in molecular biology.

Ernst Schering Research Foundation workshop·2007
Same journal

Network genomics.

Ernst Schering Research Foundation workshop·2007
Same journal

The theory of biological robustness and its implication in cancer.

Ernst Schering Research Foundation workshop·2007
See all related articles

Polycomb complexes regulate gene silencing and stem cell maintenance. This review explores their dynamic roles beyond simple silencing, including reprogramming chromatin states.

Area of Science:

  • Epigenetics and Molecular Biology

Background:

  • Polycomb complexes are crucial epigenetic regulators, primarily known for silencing homeotic genes.
  • Their functions extend to transcription activation, stem cell maintenance, cell proliferation, and oncogenesis.

Purpose of the Study:

  • To review the established roles of Polycomb complexes in gene silencing, particularly in Drosophila homeotic genes.
  • To explore the potential for Polycomb mechanisms to facilitate dynamic gene regulation and chromatin state reprogramming.

Main Methods:

  • Review of existing literature on Polycomb complexes and their functions.
  • Analysis of mechanisms governing epigenetic silencing and chromatin dynamics.

Main Results:

  • Polycomb complexes exhibit diverse regulatory functions beyond silencing homeotic genes.

Related Experiment Videos

  • Evidence suggests Polycomb mechanisms can support dynamic gene expression and chromatin remodeling.

    • Conclusions:

    • Polycomb complexes are versatile regulators involved in fundamental biological processes.
    • Further research into Polycomb-mediated dynamic regulation and chromatin reprogramming is warranted.