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[Stability of an oral liquid morphine formulation for pediatric use]
M E Morales1, V Gallardo, G López
1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Granada, Sevilla.
Objective:
The aim of this study the determination of the stability of an oral morphine hydrochloride solutions.
Method:
Determinations of a concentrated morphine solution of 4 mg/ml and the impact of two temperatures, 4 degrees C (refrigerator) and 25 degrees C (room) was analyzed via spectrophotometric measurements.
Results:
Findings showed the high stability of the solutions at 4 degrees C, since no significant degradation was observed during the 30 days of the study, whereas at room temperature stability losses were hardly seen during the first 7 days, reaching 6.8% +/- 0.5% after 15 days.
Conclusions:
The tested morphine solution is stable at 4 degrees C during 30 days, but not at room temperature.
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