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Cognitive dysfunction in the patient with antiphospholipid antibodies: considerations for cause and treatment
Melanie J Harrison1, Lisa D Ravdin
1Hospital for Special Surgery, Weill Medical College of Cornell University, Department of Medicine, New York, NY 10021, USA. harrisonM@HSS.edu
Abstract:
The evidence supporting a causal relationship between antiphospholipid (aPL) antibodies and cognitive dysfunction is very limited despite a general impression that one exists. Patients with aPL antibodies may complain of cognitive difficulties in their everyday lives, forcing the clinician to examine this issue. As with other non-thrombotic antiphospholipid syndrome (APS) manifestations, cognitive dysfunction in this population should be approached as a diagnosis of exclusion. The complexity in diagnosing and treating various manifestations of rheumatic disease holds true for identifying and addressing cognitive decline in these patients.
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