Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microdevice DNA forensics by the simple tandem repeat method.

Nils Goedecke1, Brian McKenna, Sameh El-Difrawy

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142-1479, USA.

Journal of Chromatography. A
|March 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive Groove community-based rehabilitation for older adults: study protocol for a multisite parallel randomized controlled trial.

Trials·2026
Same author

Establishing standards of care for forensic mental health: an international Delphi consensus-building study.

Frontiers in psychiatry·2026
Same author

Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial.

PloS one·2026
Same author

Long-Term Care Providers' Perspectives on Health Information Exchange During Patient Transitions Into Long-Term Care: A Multiple Case Study.

Healthcare management forum·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Development and Adoption of the Forensic Mental Health Nursing Standards of Practice for the International Association of Forensic Mental Health Services.

International journal of mental health nursing·2025
Same journal

Separation and enrichment of phages at the interface between two phases in a green solvent-based sugaring-out extraction system.

Journal of chromatography. A·2026
Same journal

Advances and perspectives in Oligo(dT) Affinity chromatography for mRNA capture: Resins, ligands and process intensification.

Journal of chromatography. A·2026
Same journal

Ion chromatography: Current strengths, key limitations, and future trends.

Journal of chromatography. A·2026
Same journal

Stereo-sensitive modelling of gas chromatographic retention indices of mono-cycloalkanes in jet fuel range.

Journal of chromatography. A·2026
Same journal

Approaches to using retention indices with coupled column pressure tuning in gas chromatography.

Journal of chromatography. A·2026
Same journal

MOF-supported surface-imprinted polymer for hazard governance of aristolochic acids in herbal matrices: A safety-control strategy supported by multiscale simulations.

Journal of chromatography. A·2026
See all related articles

New DNA forensics technology using a 16-lane microdevice with linear polyacrylamide matrices achieves high data quality for simple tandem repeat (STR) analysis. This advanced system shows promise for improved stability and complex mixture interpretation in forensic science.

Area of Science:

  • Forensic Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Current DNA forensics relies on simple tandem repeat (STR) analysis.
  • Capillary electrophoresis is a standard method for STR separation.
  • Limitations exist in throughput, stability, and complex mixture analysis.

Purpose of the Study:

  • To review experiments on a novel 16-lane micromachined device for DNA forensics.
  • To evaluate the performance of linear polyacrylamide matrices in this microdevice.
  • To assess the potential of the microdevice for analyzing complex forensic samples.

Main Methods:

  • Utilized a 16-lane micromachined device for DNA separations.
  • Employed linear polyacrylamide matrices for sample separation.

Related Experiment Videos

  • Tested full 16-locus multiplexes and multi-donor mixed samples.
  • Evaluated laser-induced fluorescence detection and data-reduction software.

    • Main Results:

    • Linear polyacrylamide matrices demonstrated high data quality metrics.
    • Successful verification of full 16-locus multiplexes on the multilane system.
    • Investigated the limits of detection and software for mixed samples.
    • The microdevice showed potential for enhanced stability over capillary arrays.

    Conclusions:

    • The 16-lane micromachined device with polyacrylamide matrices offers high-quality STR DNA forensics.
    • This technology shows promise for superior stability and improved interpretation of complex forensic mixtures.
    • The microdevice represents a potential advancement over current capillary electrophoresis systems.