Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional genomics, new tools in malaria research.

Francesco Di Girolamo1, Carla Raggi, Emanuele Bultrini

  • 1Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy.

Annali Dell'Istituto Superiore Di Sanita
|March 30, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the repertoire of rhomboid proteases in <i>Cryptosporidium parvum</i> parasite: phylogenesis, structural motifs, and cellular localization in sporozoite cells.

Frontiers in cellular and infection microbiology·2026
Same author

Identification of an immune-metabolic biosignature linking depressive symptoms and breast cancer in a clinical population.

Translational psychiatry·2026
Same author

Updating Anopheles funestus group members in Burkina Faso: species distribution and contribution to malaria transmission.

Malaria journal·2026
Same author

Dynamics of detergent-resistant membranes of Plasmodium falciparum during blood stage development.

Scientific reports·2025
Same author

A Simple and Scalable Assay for Multiplexed Flow Cytometric Profiling of Surface Markers on Small Extracellular Vesicles.

Cells·2025
Same author

An improved multiplex RT-quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections.

The Journal of antimicrobial chemotherapy·2025

Malaria remains a major global health threat, necessitating new interventions. Genomic data and functional genomics approaches offer promising avenues for developing novel malaria drugs and vaccines.

Area of Science:

  • * Parasitology
  • * Genomics
  • * Molecular Biology

Background:

  • * Malaria, caused by Plasmodium falciparum, results in over a million deaths annually, particularly in tropical and subtropical regions.
  • * Growing resistance to existing drugs and insecticides necessitates the development of novel intervention strategies.
  • * The availability of annotated genomes for Plasmodium falciparum and Plasmodium yoelii facilitates functional genomics research.

Purpose of the Study:

  • * To leverage genomic data for a comprehensive understanding of the Plasmodium life cycle.
  • * To identify potential new drug and vaccine candidates through functional genomics.
  • * To address the challenge of drug and insecticide resistance in malaria control.

Main Methods:

  • * Comparative genomics of Plasmodium falciparum and Plasmodium yoelii.

Related Experiment Videos

  • * Application of functional genomics approaches.
  • * Genome-wide transcriptome and proteome analyses in malaria parasites.

    • Main Results:

    • * Predicted gene products from annotated Plasmodium genomes.
    • * Enabled functional genomics studies for malaria parasite research.
    • * Paved the way for identifying new therapeutic and prophylactic targets.

    Conclusions:

    • * Functional genomics, aided by complete genome data, is crucial for advancing malaria research.
    • * Genome-wide studies hold significant promise for discovering new malaria interventions.
    • * Continued research is essential to combat the global burden of malaria.