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Updated: Aug 9, 2026
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
Thermodynamic study on antibacterial effect of different extracts from Radix Isatis
Yan-ling Zhao1, Fen Qu, Xiao-he Xiao
1Institute of Chinese Materia Medica, The 302 Hospital of PLA, Beijing 100039. zhao2855@263.net
Objective:
To study and analyze the antibacterial effects of different extracts from Radix Isatis.
Methods:
Staphylococcus aureus was used as the studied object in the experiment. Antibacterial effects of extracts from Radix Isatis were observed by thermocalrimetry on Staphylococcus aureus, together with common pharmacological experiments.
Results:
The total extract, ethyl acetate (EtOAc) extract, n-butylalcohol (nBuOH) extract, chloroform (CHCl(3)) extract and petroleum (P.E.) extract had antiviral effects to some extent while the residue after extracting had no antibacterial activity. The potency of antiviral activity among them was as follows: nBuOH extract > EtOAc extract > CHCl(3) extract > total extract > P.E. extract.
Conclusion:
The antibacteriall effects of Radix Isatis were not limited to any active portion, showing that Radix Isatis exerts its antibacterial effects by cooperation of different active fractions in varied ways.
