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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Isolated massive thyroid metastasis in lung cancer
S K Bandyopadhyay1, R Bandyopadhyay, A Dutta
1Department of Medicine, Nil Ratan Sircar Medical College and Hospital, Calcutta. drsanjay_b@rediffmail.com
Singapore Medical Journal
|March 31, 2006
Summary
Metastasis of lung cancer to the thyroid is uncommon but can lead to significant gland enlargement. This rare occurrence in squamous cell carcinoma signals a poor prognosis, with survival typically around two months.
Area of Science:
- Oncology
- Endocrinology
- Pulmonology
Background:
- Thyroid gland metastasis is rare, despite its rich vascularity.
- Lung carcinoma is the most common pulmonary malignancy to metastasize to the thyroid.
- Metastatic lung cancer to the thyroid portends a poor prognosis, with average survival of two months.
Observation:
- A 62-year-old woman presented with massive thyroid gland enlargement.
- The thyroid enlargement was caused by metastatic squamous cell carcinoma of the lung.
- The metastatic disease in the thyroid preceded the diagnosis of the primary lung cancer by several months.
Findings:
- Squamous cell carcinoma of the lung can metastasize to the thyroid gland.
- Metastasis can manifest as massive thyroid enlargement.
- Metastasis to the thyroid can precede the diagnosis of the primary lung malignancy.
Implications:
- This case highlights an unusual presentation of lung cancer metastasis.
- Early recognition of thyroid metastasis from lung cancer is crucial for patient management.
- Further research into the mechanisms and clinical implications of rare thyroid metastases is warranted.

