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Related Experiment Videos

Factor X deficiency presenting as a pseudotumor. Case report.

Jecko V Thachil1, Mark Caswell, Russell Keenan

  • 1Department of Haematology, Royal Liverpool Children's Hospital NHS Trust, Alder Hey, Liverpool, United Kingdom.

Journal of Neurosurgery
|April 1, 2006
PubMed
Summary

Congenital factor X deficiency can cause spontaneous intracerebral hemorrhage in infants. Early diagnosis and treatment are crucial for complete recovery and normal development.

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Area of Science:

  • Pediatric Neurology
  • Hematology
  • Medical Genetics

Background:

  • Spontaneous intracerebral hemorrhage in infants is a rare and serious condition.
  • Differential diagnosis often includes brain tumors, but underlying coagulopathies should also be considered.

Observation:

  • A 15-week-old infant presented with coma due to spontaneous intracerebral hemorrhage.
  • Initial imaging suggested a right frontal lobe tumor; coagulation studies were abnormal.
  • The infant underwent emergency craniotomy for hematoma evacuation and biopsy.

Findings:

  • Postoperative recovery was complete.
  • Detailed coagulation studies identified congenital factor X deficiency.
  • Histological analysis revealed normal brain tissue with hemorrhagic infiltration, ruling out a tumor.

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Implications:

  • Congenital bleeding disorders, such as factor X deficiency, must be considered in the evaluation of infantile intracerebral hemorrhage.
  • Prompt diagnosis and management of coagulopathies can lead to favorable neurological outcomes.
  • This case highlights the importance of comprehensive coagulation screening in neonates and infants with unexplained intracranial bleeding.