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Oligomerization of nitrophorins

Attila Ambrus1, Kenneth Friedrich, Arpád Somogyi

  • 1Department of Pharmacology and Toxicology, University of Arizona, Tucson, 85721, USA. ambrus@pharmacy.arizona.edu

Analytical Biochemistry
|April 1, 2006
PubMed
Summary

Nitrophorin (NP) proteins in Rhodnius prolixus facilitate nitric oxide (NO) delivery. This study reveals that NPs form pH- and ligand-dependent oligomers, crucial for efficient NO storage and release in insect saliva and hosts.

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