Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imprinting the Gnas locus.

A Plagge1, G Kelsey

  • 1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK. antonius.plagge@bbsrc.ac.uk

Cytogenetic and Genome Research
|April 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A distinctive epigenetic ageing profile in human granulosa cells.

Human reproduction (Oxford, England)·2020
Same author

Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques.

Molecular imaging and biology·2020
Same author

Anti-Xa levels with low molecular weight heparin calibrator can be used to exclude significant apixaban effect.

Pathology·2019
Same author

DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in polycystic ovary syndrome patients.

Human reproduction (Oxford, England)·2019
Same author

Impulsive choices in mice lacking imprinted Nesp55.

Genes, brain, and behavior·2016
Same author

The specification of imprints in mammals.

Heredity·2014
Same journal

Genomic Organization of Ribosomal DNA and Karyotypic Diversity in Vicia sativa and Vicia villosa.

Cytogenetic and genome research·2026
Same journal

George Martin and Werner's Syndrome.

Cytogenetic and genome research·2026
Same journal

The Spectrum of Mosaic Double Aneuploidy of Monosomy X and Trisomy 18: Two New Cases and Review of the Literature.

Cytogenetic and genome research·2026
Same journal

Familial Robertsonian Translocation, rob(14;21), with High Risk for Down Syndrome.

Cytogenetic and genome research·2026
Same journal

Radiosensitivity and Bystander Response in X-Ray-Irradiated Tumour and Normal Epithelial Cells of Breast and Prostate Origin.

Cytogenetic and genome research·2026
Same journal

Cytogenetic Profile of Acute Lymphoblastic Leukaemia in South India: A Series of 1,819 Patients from a Single Centre.

Cytogenetic and genome research·2026
See all related articles

The Gnas locus is a complex imprinted gene region encoding multiple proteins, including Gsalpha, XLalphas, and Nesp55. This review explores its discovery, mutation consequences, and evolutionary significance.

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • The Gnas locus is a complex imprinted gene region.
  • It encodes multiple proteins, including Gsalpha, XLalphas, and Nesp55, through alternative transcripts.
  • Imprinting patterns vary across tissues and parental origins.

Purpose of the Study:

  • To review the discovery of Gnas imprinting.
  • To examine the phenotypic consequences of Gnas gene product mutations in mice and humans.
  • To propose explanations for the evolution of this complex imprinted locus.

Main Methods:

  • Literature review of genetic imprinting studies.
  • Analysis of phenotypic data from mouse and human Gnas mutation studies.
  • Comparative genomics and evolutionary analysis.

Related Experiment Videos

Main Results:

  • Gnas encodes Gsalpha, XLalphas, and Nesp55 via overlapping transcripts with distinct imprinting.
  • Gsalpha is a key signaling protein involved in growth and homeostasis.
  • Mutations in Gnas products lead to various phenotypic consequences in mammals.

Conclusions:

  • The Gnas locus exhibits intricate imprinting with tissue-specific expression.
  • Understanding Gnas imprinting provides insights into mammalian development and disease.
  • The evolutionary pressures driving the complexity of the Gnas locus are multifaceted.