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Primary laryngeal lymphoma: case report.

Ronnie Word¹, Andrew C Urquhart, Victor S Ejercito

¹Department of Otolaryngology-Head and Neck Surgery, Marshfield Clinic, Marshfield, WI 54449, USA.

Ear, Nose, & Throat Journal

|April 4, 2006

Summary

Primary laryngeal lymphoma, a rare cancer, can cause hoarseness. This case shows successful treatment with chemotherapy and rituximab, highlighting the need for early diagnosis of this laryngeal tumor.

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Area of Science:

Oncology
Hematology
Otolaryngology

Background:

Extranodal laryngeal lymphoma is an exceptionally rare clinical finding.
Primary laryngeal lymphoma requires careful consideration in the differential diagnosis of laryngeal masses.

Observation:

A 76-year-old male presented with a 7-week history of progressive hoarseness.
Laryngoscopy revealed asymmetry of the right false vocal fold, prompting further investigation.

Findings:

A deep biopsy confirmed a diagnosis of malignant, diffuse, CD20-positive, B-cell lymphoma.
The patient's stage IE lymphoma achieved complete remission following treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy combined with rituximab.

Implications:

Early detection and prompt treatment are crucial for favorable outcomes in laryngeal lymphoma.
Vigilance for this rare laryngeal tumor is warranted due to the potential severity of a missed diagnosis.

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