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Updated: Aug 9, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
Growth factor receptors in helminth parasites: signalling and host-parasite relationships
Colette Dissous1, Naji Khayath, Jérôme Vicogne
1Unité Inserm 547, Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex, France. colette.dissous@pasteur-lille.fr
Abstract:
Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.
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