Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphonuclear neutrophil function in recurrent aphthous stomatitis.

D Wray1, J Charon

  • 1Department of Oral Medicine & Oral Pathology, University of Edinburgh, Scotland.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Report of Lethal Yellowing Disease of Coconut Palms Caused by Phytoplasma on Nevis Island.

Plant disease·2019
Same author

Probing the surfaces of core-shell and hollow nanoparticles by solvent relaxation NMR.

Magnetic resonance in chemistry : MRC·2017
Same author

Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same author

Antistaphylococcal β-Lactams versus Vancomycin for Treatment of Infective Endocarditis Due to Methicillin-Susceptible Coagulase-Negative Staphylococci: a Prospective Cohort Study from the International Collaboration on Endocarditis.

Antimicrobial agents and chemotherapy·2016
Same author

Report on World Workshops on Oral Medicine (WWOM) IV and V: research themes and citation impact: WWOM VI steering committee.

Oral diseases·2014
Same author

Repeat endocarditis: analysis of risk factors based on the International Collaboration on Endocarditis - Prospective Cohort Study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2013
Same journal

Predictors of Lesion Detection in a 12-Year Oral Cancer Screening Program: A Cohort Study in Northern Portugal.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same journal

Inhibition of the EP300/Notch Signaling Pathway Regulates Proliferation and Apoptosis in Oral Squamous Cell Carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same journal

Prognostic Value of Bcl-xL in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same journal

Oral Epithelial Dysplasia Information Needs Questionnaire (ODIN-Q): Responsiveness and Insights Into Patient Education.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same journal

Bridging the Health Literacy Gap for Patients With Oral Cancer: Readability Enhancement With AI Chatbots.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same journal

Rapamycin Targets Cancer Stem Cells to Decrease Cisplatin Resistance in a Head and Neck Cancer Mouse Xenograft Model.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
See all related articles

Polymorphonuclear neutrophils (PMN) in recurrent aphthous stomatitis (RAS) show reduced serum-mediated adherence. This suggests humoral factors may contribute to the persistence of oral ulcers in RAS patients.

Area of Science:

  • Immunology
  • Oral Pathology

Background:

  • Recurrent aphthous stomatitis (RAS) is characterized by recurrent oral ulcerations.
  • Polymorphonuclear neutrophils (PMN) are the primary cells found in established RAS lesions.

Purpose of the Study:

  • To investigate the function of PMN in patients with RAS.
  • To compare PMN oxidative metabolism and adherence in RAS patients versus healthy controls.

Main Methods:

  • Assessed oxygen radical production using cytochrome-c and nitroblue tetrazolium (NBT) dye reduction assays.
  • Measured PMN adherence to glass surfaces.
  • Evaluated the effect of patient and control serum on PMN adherence, with and without phorbol myristate acetate (PMA) stimulation.

Main Results:

Related Experiment Videos

  • Oxidative metabolism of PMN was similar between RAS patients and controls.
  • Serum significantly reduced PMN adherence in both groups.
  • Serum from RAS patients showed a lesser inhibitory effect on PMN adherence compared to control serum.
  • Phorbol myristate acetate (PMA) stimulation reversed the serum-mediated effect on adherence.

Conclusions:

  • Humoral factors in RAS patients may impair serum's ability to inhibit PMN adherence.
  • Increased adherence of stimulated PMN, influenced by serum factors, could play a role in the chronicity of RAS lesions.