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Bone marrow angiogenesis in aplastic anemia.

Jian-Ling Ji1, Mei-Yu Xu, Feng Huang

  • 1Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|April 6, 2006
PubMed
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Bone marrow angiogenesis is reduced in aplastic anemia (AA). This study found lower microvessel density in AA patients, suggesting impaired blood vessel formation contributes to the condition.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Aplastic anemia (AA) is a rare but serious blood disorder.
  • The role of bone marrow angiogenesis in AA pathogenesis is not well understood.

Purpose of the Study:

  • To investigate the status of bone marrow angiogenesis in patients with aplastic anemia.
  • To compare microvessel density (MVD) and angiogenesis grading in AA patients versus healthy controls.

Main Methods:

  • Bone marrow specimens from 32 AA patients and 16 controls were analyzed.
  • Immunohistochemical staining for CD34 was used to identify microvessels.
  • Microvessel density (MVD) and angiogenesis grading were assessed in a blinded manner.

Main Results:

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  • Bone marrow MVD was significantly lower in AA patients compared to controls (P < 0.01).
  • MVD was reduced in both severe and moderate AA cases versus controls (P < 0.01).
  • A significant difference in MVD was observed between severe and moderate AA (P < 0.05).
  • Angiogenesis grade and MVD showed a positive correlation in AA patients (r = 0.64, P < 0.01).

Conclusions:

  • Bone marrow angiogenesis is impaired in patients with aplastic anemia.
  • Defective angiogenesis may contribute to the development or exacerbation of hematopoietic aplasia in AA.