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Updated: Aug 9, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Conformation of uncomplexed natural antamanide crystallized from CH(3)CN/H(2)O
I L Karle1, T Wieland, D Schermer
1Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, D.C. 20375.
Abstract:
Natural antamanide, a cyclic decapeptide from Amanita phalloides, has been shown to have the same conformation for the backbone and comparable side groups as the biologically active synthetic [Phe(4), Val(6)]antamanide. Packing in the crystal is quite different for the two compounds. Large channels with a polar lining are formed in the crystals of [Phe(4), Val(6)]antamanide, whereas in natural antamanide large channels in the crystal are completely surrounded by the lipophilic side groups of the Pro, Phe, and Ala residues. Antamanide, C(64)H(78)N(10)O(10).8H(2)O.X, crystallizes in space group P2(1)2(1)2(1) with a = 15.88 A, b = 34.88 A, and c = 13.61 A.
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