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Embryonic karyotype in recurrent miscarriage with parental karyotypic aberrations
Howard Carp1, Esther Guetta, Haya Dorf
1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. carp@netvision.net.il
Fertility and Sterility
|April 6, 2006
Summary
Parental chromosomal aberrations are not highly predictive of miscarriage due to fetal chromosomal abnormalities. While parental aberrations were found in 10% of cases, most miscarriages were euploidic.
Area of Science:
- Genetics
- Reproductive Medicine
- Cytogenetics
Background:
- Recurrent miscarriage affects a significant number of couples.
- Parental chromosomal aberrations are a known risk factor for recurrent miscarriage.
- Identifying the cause of miscarriage is crucial for reproductive counseling.
Purpose of the Study:
- To evaluate the predictive value of parental chromosomal aberrations for fetal chromosomal abnormalities in recurrent miscarriage.
- To determine the incidence of chromosomal aberrations in abortuses from couples with and without parental chromosomal aberrations.
Main Methods:
- A retrospective comparative cohort study was conducted.
- Karyotyping was performed on parents and abortuses from 1108 patients with 3-16 miscarriages.
- Abortuses were analyzed for euploidy, aneuploidy, and structural rearrangements.
Main Results:
- Of 203 successfully karyotyped abortuses, 23.2% had chromosomal aberrations when parents had normal karyotypes.
- In patients with parental chromosomal aberrations, 30.8% of abortuses showed abnormal karyotypes, a difference not statistically significant.
- Parental aberrations were transmitted to the abortus in only 10% of cases.
Conclusions:
- Parental karyotyping has limited predictive value for identifying chromosomal aberrations in subsequent miscarriages.
- A significant proportion of abortuses in recurrent miscarriage are euploidic, even with parental aberrations.
- Further investigation is needed to understand the etiology of recurrent miscarriage.
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