Related Experiment Video
Updated: Aug 9, 2026

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
Published on: October 13, 2019
Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis
Jifen Li1, Vickas V Patel, Glenn L Radice
1Center for Research on Reproduction and Women's Health, University of Pennsylvania, 1355 Biomedical Research Building II/III, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA.
Abstract:
Proper mechanical and electrical coupling of cardiomyocytes is crucial for normal propagation of the electrical impulse throughout the working myocardium. Various proteins on the surface of cardiomyocytes are responsible for the integration of structural information and cell-cell communication. Increasing evidence from diseased myocardium and animal models indicates that alteration in electrical coupling via gap junctions is a critical determinant in the development of an arrhythmogenic substrate. What is less clear is how gap junctions are maintained and regulated in the working myocardium. In this review, we present data from human disease and animal models that support the idea that cell adhesion proteins regulate the stability of the gap junction protein, connexin.
Related Concept Videos
Mechanism of Cardiac Arrhythmias
Intracellular Signaling Affects Focal Adhesions
Some...
Electrophysiology of Normal Cardiac Rhythm
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Adherens Junctions
Adherens Junctions are Dynamic
The endothelial cells...
