Multicentric, synchronous giant-cell tumor of bone
Turgay Cavusoglu1, Alpaslan Senkoylu, Hakan Ozsoy
1Ministry of Health, Ankara Research and Education Hospital, First Orthopedics and Traumatology Clinic, Cebeci, Ankara, Turkey.
Saudi Medical Journal
|April 7, 2006
Summary
Multicentric giant cell tumors are rare bone lesions. This case highlights a synchronous multicentric giant cell tumor in a 15-year-old female patient.
Area of Science:
- Orthopedic Oncology
- Pathology
Background:
- Giant cell tumor (GCT) is a common primary bone tumor, typically occurring in skeletally mature individuals.
- Multicentric giant cell tumor (MGCT) represents a rare variant with multiple simultaneous GCTs.
- The synchronous type of MGCT, where tumors appear concurrently, is exceptionally uncommon.
Observation:
- A 15-year-old female presented with synchronous multicentric giant cell tumor.
- This presentation is unusual given the patient's young age and the synchronous nature of the lesions.
- Detailed clinical and radiological evaluation was performed.
Findings:
- The case confirmed a diagnosis of synchronous multicentric giant cell tumor.
- Histopathological examination revealed characteristic giant cells and stromal cells.
- The synchronous presentation in a pediatric patient is a key finding.
Implications:
- This case expands the understanding of MGCT presentation and demographics.
- It underscores the importance of considering rare variants in young patients with bone tumors.
- Further research into the etiology and management of synchronous MGCT is warranted.
Related Concept Videos
01:09Spongy Bone
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:27Compact Bone
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:17Gross Anatomy of Bone
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...