Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function in anaphylaxis.

A Kasperska-Zajaç1, B Rogala

  • 1Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology in Zabrze, Medical University of Silesia, Poland. kasperska@plusnet.pl

Journal of Investigational Allergology & Clinical Immunology
|April 8, 2006
PubMed
Summary

Human platelets play a key role in anaphylaxis by releasing mediators and participating in hypersensitivity reactions. This review examines platelet function in anaphylactic events, highlighting their involvement in allergic responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy·2026
Same author

Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery.

Obesity surgery·2019
Same author

Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2019
Same author

Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2018
Same author

Overweight and obesity may play a role in the pathogenesis of chronic spontaneous urticaria.

Clinical and experimental dermatology·2018
Same author

Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria.

Journal of biological regulators and homeostatic agents·2017

Area of Science:

  • Immunology
  • Hematology
  • Allergy Research

Background:

  • Human platelets are involved in immune responses and hypersensitivity reactions like anaphylaxis.
  • Platelets express functional receptors for Immunoglobulin E (IgE), enabling IgE-mediated activation.
  • Altered platelet function is observed in allergic conditions and hypersensitivity reactions.

Purpose of the Study:

  • To review and summarize current knowledge on platelet function during anaphylactic reactions.
  • To explore the role of platelets in IgE-mediated hypersensitivity.
  • To consolidate findings from human and experimental studies on platelets in anaphylaxis.

Main Methods:

  • Literature review of human and experimental studies.
  • Analysis of data on platelet activation and mediator release.

Related Experiment Videos

  • Examination of platelet involvement in hypersensitivity and anaphylactic shock.

    • Main Results:

    • Platelets actively participate in anaphylaxis through mediator release and immune cell interactions.
    • IgE receptors (Fc epsilonRII and Fc epsilonRI) on platelets facilitate activation.
    • Anaphylactic shock is associated with hemostatic disturbances, including thrombocytopenia (low platelet count).

    Conclusions:

    • Human platelets are crucial effectors in anaphylactic reactions.
    • Understanding platelet function in anaphylaxis is vital for managing hypersensitivity disorders.
    • Platelet activation and subsequent mediator release contribute significantly to anaphylaxis pathophysiology.