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Synthesis and structure revision of calyxin natural products
Xia Tian1, James J Jaber, Scott D Rychnovsky
1Department of Chemistry, 516 Rowland Hall, University of California, Irvine, Irvine, California 92697, USA.
Abstract:
Tandem Prins cyclization and Friedel-Crafts reaction with an electron-rich aromatic ring were used to prepare the core structures of calyxin natural products. The proposed structure of epicalyxin F was prepared and shown to be incorrect. Several calyxin natural products, including calyxin F and L, were synthesized, and the structures were reassigned on the basis of NMR data and synthetic correlations.
