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Updated: Aug 9, 2026
07:10
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Is SAPHO syndrome a target for antibiotic therapy?
1The B. Shine Department of Rheumatology, Rambam Medical Center and B. Rappaport Faculty of Medicine, Israel-Technion Institute of Technology, 9602, Haifa 31096, Israel. a_rozin@rambam.health.gov.il
Clinical Rheumatology
|April 8, 2006
Summary
This study reports a potential link between Staphylococcus aureus infection and Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome. Treatment with co-trimoxazole showed promising results.
Area of Science:
- Rheumatology
- Dermatology
- Infectious Diseases
Background:
- The exact cause of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome is unknown.
- Infectious agents are suspected to play a role in SAPHO syndrome's development.
Observation:
- This case report details a potential association between Staphylococcus aureus infection from a plantar pustule and SAPHO syndrome.
- Successful treatment was achieved using co-trimoxazole (sulfamethoxazole/trimetoprim).
Findings:
- This is the first reported case suggesting Staphylococcus aureus as a potential trigger for SAPHO syndrome.
- Co-trimoxazole demonstrated efficacy, possibly due to its dual antibiotic and immunomodulatory actions.
Implications:
- Co-trimoxazole may be a preferred treatment for SAPHO syndrome.
- In vitro hypersensitivity testing identified potential severe reactions to co-trimoxazole before treatment.
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