Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pyoderma gangrenosum associated with ulcerative colitis.

Suzana Ljubojević1, Visnja Milavec-Puretić, Vesna Sredoja-Tisma

  • 1University Department of Dermatology and Venereology, Zagreb University Hospital Center, Salata 4, HR-10000 Zagreb, Croatia. suzana.ljubojevic@zg.htnet.hr

Acta Dermatovenerologica Croatica : ADC
|April 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regular arrangement of collecting venules as a predictor of <i>Helicobacter pylori</i> absence using white-light endoscopy: a multicenter prospective study outside Asia.

Therapeutic advances in gastrointestinal endoscopy·2025
Same author

Management of gastrointestinal bleeding in a patient with type 3 von Willebrand disease and inhibitors to von Willebrand factor: a case report.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2025
Same author

Dermoscopic and trichoscopic features of follicular mycosis fungoides: a systematic review.

Italian journal of dermatology and venereology·2025
Same author

CROATIAN GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF PORTAL HYPERTENSION.

Acta clinica Croatica·2025
Same author

Establishment of standards for the referral of large nonpedunculated colorectal polyps: an international expert consensus using a modified Delphi process.

Gastrointestinal endoscopy·2024
Same author

Melanoma Developing from an Intradermal Nevus: Report on Two Patients.

Acta dermatovenerologica Croatica : ADC·2023

This case study details a patient with pyoderma gangrenosum (PG) and ulcerative colitis, highlighting the challenges in managing these interconnected inflammatory conditions. Treatment resistance and disease flares underscore the complexity of PG and inflammatory bowel disease.

Area of Science:

  • Dermatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis often associated with systemic diseases.
  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that can sometimes manifest with extraintestinal complications like PG.

Observation:

  • A 45-year-old male presented with extensive, non-healing ulcers on his chest, back, and face, clinically and histopathologically diagnosed as PG.
  • The patient had a six-month history of diagnosed ulcerative colitis, with current colonoscopy revealing pancolitis.
  • Initial treatment with high-dose glucocorticosteroids, sulfasalazine, and antibiotics led to partial ulcer regression, but new lesions emerged upon dose tapering, alongside E. coli sepsis and UC flare.

Findings:

  • The patient's PG presented as rapidly enlarging, painful ulcers with characteristic undermined borders and necrotic bases.

Related Experiment Videos

  • Recurrence of PG ulcers and UC exacerbation occurred during glucocorticosteroid dose reduction, indicating treatment resistance.
  • The case illustrates a complex interplay between severe PG and active inflammatory bowel disease.

    • Implications:

    • Management of pyoderma gangrenosum associated with ulcerative colitis is challenging and often requires multidisciplinary approaches.
    • Therapeutic strategies may involve optimizing IBD treatment, immunomodulators like azathioprine, and potentially surgical intervention (colectomy).
    • Further research into the pathogenesis and targeted therapies for PG-IBD overlap syndromes is warranted.