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Related Experiment Videos

Striatal dysfunction in schizophrenia and unaffected relatives.

Matthijs Vink1, Nick F Ramsey, Mathijs Raemaekers

  • 1Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan, Utrecht, the Netherlands.

Biological Psychiatry
|April 11, 2006
PubMed
Summary

Schizophrenia patients and their siblings show abnormal striatal activation during inhibitory control tasks, suggesting a potential genetic risk for the disorder. This brain abnormality may underlie impaired inhibitory control in schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is linked to deficits in inhibitory control.
  • The striatum plays a crucial role in inhibitory control.
  • Investigating striatal function in schizophrenia and at-risk individuals is important.

Purpose of the Study:

  • To examine striatal activation during inhibitory control in schizophrenia patients and their first-degree relatives.
  • To determine if abnormal striatal activation is specific to schizophrenia or indicative of illness risk.

Main Methods:

  • Functional MRI and behavioral data were collected during an inhibitory control task.
  • Participants included 21 schizophrenia patients, 15 unaffected siblings, and 36 controls.
  • The task involved inhibiting responses to stop cues with increasing predictability.

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Main Results:

  • Control subjects exhibited anticipatory striatal activation that increased with inhibitory demand.
  • Schizophrenia patients and their siblings failed to show this anticipatory striatal activation.
  • Behavioral impairments in inhibitory control were observed only in patients.

Conclusions:

  • Striatal abnormalities are present in both schizophrenia patients and unaffected siblings.
  • These abnormalities may reflect a heightened genetic risk for developing schizophrenia.
  • Striatal dysfunction could be a key neural correlate of schizophrenia risk.