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Related Experiment Videos

Synovial sarcoma: a clinicopathological review.

S A Henderson1, R Davis, J R Nixon

  • 1Department of Orthopaedics, Musgrave Park Hospital, Belfast, Northern Ireland.

International Orthopaedics
|January 1, 1991
PubMed
Summary

Synovial sarcoma, a rare soft tissue tumor, often presents in young adults with delayed diagnosis. Mitotic activity is a key prognostic indicator, and wide surgical excision is the primary treatment.

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Synovial sarcoma is a malignant soft tissue tumor.
  • It typically affects young adults, often in the extremities.
  • Diagnosis can be challenging due to non-specific clinical and radiological findings.

Purpose of the Study:

  • To review clinical and pathological features of synovial sarcoma.
  • To identify prognostic factors and optimal treatment strategies.
  • To emphasize the importance of early diagnosis.

Main Methods:

  • Retrospective review of 20 synovial sarcoma cases.
  • Analysis of clinical presentation, pathological findings, and treatment outcomes.
  • Evaluation of prognostic indicators, including mitotic activity.

Main Results:

  • Tumors commonly occurred in the leg of young adults with a prolonged history.
  • Clinical and radiological data were not definitive for early diagnosis.
  • The five-year survival rate was 43%.
  • High mitotic activity correlated with poorer prognosis.

Conclusions:

  • A high index of suspicion is crucial for timely diagnosis of synovial sarcoma.
  • Mitotic activity is a significant prognostic factor.
  • Adequate wide excision is the cornerstone of treatment.

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