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Updated: Jan 31, 2026

Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish
09:06

Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish

Published on: May 4, 2017

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Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven

Hao Mo1, Marie Henriksson

  • 1Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden.

Proceedings of the National Academy of Sciences of the United States of America
|April 12, 2006
PubMed

Insights

Researchers discovered novel compounds that target the Myc oncoprotein, a key driver of cancer. These Myc pathway response agents (MYRAs) show potential for cancer therapy by inducing cancer cell death and inhibiting tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • The Myc transcription factor is crucial for cell growth and is frequently dysregulated in human cancers.
  • Myc's role in cell cycle, apoptosis, and angiogenesis makes it a significant target for cancer therapeutics.

Purpose of the Study:

  • To identify small molecules that modulate the Myc pathway for potential cancer therapy.
  • To investigate compounds that induce apoptosis and inhibit Myc-driven cellular transformation.

Main Methods:

  • Utilized a cellular screening approach to identify Myc pathway response agents (MYRAs).
  • Characterized the mechanism of action for two identified compounds, MYRA-A and MYRA-B.

Main Results:

  • Identified MYRAs that induce c-Myc-dependent apoptosis and inhibit Myc-driven transformation.
  • MYRA-A inhibits Myc transactivation and DNA binding; MYRA-B induces apoptosis independently of these mechanisms.
  • Demonstrated the efficacy of cellular screening for discovering pathway-modulating agents.

Conclusions:

  • Cellular screening is an effective strategy for identifying compounds targeting the Myc pathway.
  • MYRAs represent promising leads for developing novel cancer therapies targeting Myc.
  • These compounds can serve as valuable tools for further Myc pathway research.

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