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[Membrane-selective electrodes for drug analysis. Note II].

Nela Bibire¹, V Dorneanu

¹Universitatea de Medicină gi Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|April 13, 2006

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Seven new PVC matrix and liquid-membrane electrodes were developed for N-butylscopolamine bromide detection. These sensors offer a sensitive and reliable method for analyzing pharmaceutical formulations.

Area of Science:

Analytical Chemistry
Electrochemistry
Materials Science

Context:

Development of novel ion-selective electrodes (ISEs) is crucial for accurate pharmaceutical analysis.
N-butylscopolamine bromide is an important pharmaceutical compound requiring precise quantification.
Polyvinyl chloride (PVC) and liquid-membrane matrices offer versatile platforms for electrode fabrication.

Purpose:

To design and characterize seven novel membrane-selective electrodes for N-butylscopolamine bromide.
To evaluate the performance of these electrodes in terms of linearity, detection limit, and recovery.
To demonstrate the applicability of the developed electrodes for the quantitative assay of N-butylscopolamine bromide in pharmaceutical formulations.

Summary:

Seven polyvinyl chloride (PVC) matrix and liquid-membrane electrodes incorporating different electroactive materials were fabricated for N-butylscopolamine detection.

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The electrodes exhibited a linear potentiometric response for N-butylscopolamine bromide over a concentration range of 10⁻⁶ to 10⁻² M, with detection limits ranging from 4.58 x 10⁻⁷ M to 1.09 x 10⁻⁶ M.

Quantitative analysis of N-butylscopolamine bromide in pharmaceutical formulations using direct potentiometry and potentiometric titration yielded high recovery rates (95.50%–99.20%).

Impact:

Provides a sensitive and selective electrochemical method for the quantification of N-butylscopolamine bromide.
Demonstrates the utility of PVC and liquid-membrane electrodes in pharmaceutical quality control.
Offers a reliable tool for the assay of N-butylscopolamine bromide in injectable solutions, ensuring drug safety and efficacy.