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Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing
Tudor Bibire1,2, Alina-Diana Panainte3, Catalina Natalia Yilmaz4
1Department of Surgery, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy from Iasi, 16th Universitatii Street, 700116 Iasi, Romania.
International Journal of Molecular Sciences
|April 17, 2025
Summary
This study developed a novel hydrogel for wound healing. The dexketoprofen-loaded hydrogel demonstrated effective wound closure and reduced inflammation, showing potential for accelerated healing.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Wound Healing Research
Background:
- Current wound management strategies have limitations, necessitating novel therapeutic approaches.
- Hydrogels derived from natural polymers offer promising advantages for wound care, including pain reduction, infection control, and targeted drug delivery.
- There is a significant need for advanced wound healing treatments to improve patient outcomes.
Purpose of the Study:
- To develop and characterize an alginate-grafted N-vinylcaprolactam-based thermo-responsive hydrogel.
- To investigate the modified release of dexketoprofen (DEX) from the developed hydrogel matrix.
- To evaluate the potential of the hydrogel for enhanced wound healing applications.
Main Methods:
- Synthesis of thermo-responsive hydrogels using free radical polymerization and grafting techniques.
- Characterization of unloaded hydrogel (HY) and dexketoprofen-loaded hydrogel (DEXHY).
- In vitro assessment of cell viability, drug release kinetics, and wound closure rate.
Main Results:
- The dexketoprofen-loaded hydrogel (DEXHY) successfully encapsulated dexketoprofen at a concentration of 4 mg/mL.
- DEXHY demonstrated a good in vitro wound closure rate and maintained significant cell viability (75.4%).
- The hydrogel effectively modified the release kinetics of dexketoprofen, indicating controlled drug delivery.
Conclusions:
- The developed alginate-grafted N-vinylcaprolactam hydrogel shows significant potential for wound healing applications.
- The hydrogel's ability to control dexketoprofen release and reduce inflammation can facilitate and accelerate the healing process.
- This novel hydrogel system offers a promising therapeutic option for various wound types, including surgical wounds.
Keywords:
dexketoprofengraft copolymerizationpoly(N-vinylcaprolactam)sodium alginatethermo-responsive matrixwound healingMore Related Videos
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