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Zeptogram-scale nanomechanical mass sensing.

Y T Yang1, C Callegari, X L Feng

  • 1Kavli Nanoscience Institute, California Institute of Technology, Mail Code 114-36, Pasadena, California 91125, USA.

Nano Letters
|April 13, 2006
PubMed
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Very high frequency nanoelectromechanical systems (NEMS) achieve highly sensitive, real-time inertial mass sensing. These systems demonstrate potential for resolving individual macromolecules with single-Dalton precision.

Area of Science:

  • Physics
  • Nanotechnology
  • Materials Science

Background:

  • Nanoelectromechanical systems (NEMS) are increasingly utilized for high-sensitivity measurements.
  • Inertial mass sensing with NEMS offers a pathway to detect minute mass changes.

Purpose of the Study:

  • To demonstrate real-time, in situ inertial mass sensing using very high frequency (VHF) NEMS.
  • To assess the ultimate mass resolution capabilities of VHF NEMS.

Main Methods:

  • Fabrication and operation of VHF NEMS devices.
  • In situ mass sensing measurements with real-time data acquisition.
  • Analysis of mass noise floor and mass resolution.

Main Results:

  • Achieved a mass noise floor of approximately 20 zeptograms (zg).

Related Experiment Videos

  • Demonstrated a best mass resolution of approximately 7 zg, equivalent to ~30 xenon atoms or a 4 kDa molecule.
  • Experimental data suggests potential for single-Dalton resolution.

    • Conclusions:

    • VHF NEMS exhibit exceptional sensitivity for inertial mass sensing.
    • These devices hold promise for detecting individual macromolecules.
    • Future advancements could enable single-Dalton resolution for intact, neutral macromolecules.