[Preliminary study of cervicovaginal peroxidase as indicator for ovulation]

The study was designed to determine whether the change in the pattern of cervicovaginal peroxidase activity in the fertile period of women can serve as a basis for the development of a technique to predict ovulation time in natural family planning. Eight healthy women volunteered for this study in Chengdu area. The samples of cervical mucus and vaginal secretion were collected. The specific G-Px activity was measured with reference to the procedure of Tsibris, et al., on days 6, 8, 10, 12 through 16, 18, 20, 22, 24 of each menstrual cycle; at the same time an antecubital venous blood sample was drawn to be analyzed for levels of LH, FSH, E2, and P by RIA. The data showed that in 7 ovulatory cycles the G-Px activity did not vary regularly in vaginal secretion but it did drop rapidly in cervical mucus 2 or 3 days before ovulation time and it rose again one day after ovulation. The results suggest that the measurement of the G-Px activity in cervical mucus can be used to predict ovulation by two to three days before the time.