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Relation between acute urinary retention, chronic prostatic inflammation and accompanying elevated prostate-specific
Aykut Kefi1, Hikmet Koseoglu, Ilhan Celebi
1Department of Urology, Medical Faculty, Dokuz Eylul University, Izmir, Turkey. a.kefi@deu.edu.tr
Scandinavian Journal of Urology and Nephrology
|April 13, 2006
Summary
Chronic prostatic inflammation is linked to elevated prostate-specific antigen (PSA) levels and acute urinary retention (AUR). This inflammation may contribute to the development of AUR in men with benign prostatic obstruction.
Area of Science:
- Urology
- Pathology
Background:
- Benign prostatic obstruction (BPO) can lead to acute urinary retention (AUR).
- The role of chronic prostatic inflammation and prostate-specific antigen (PSA) levels in AUR is not fully understood.
Purpose of the Study:
- To investigate the association between acute urinary retention (AUR), prostate-specific antigen (PSA) levels, and chronic prostatic inflammation.
Main Methods:
- A retrospective case-control study compared 64 patients with AUR and 168 without AUR who underwent transurethral resection of the prostate (TURP) for BPO.
- Statistical analyses included Chi-squared tests and multiple linear regression to assess relationships.
Main Results:
- Patients with AUR showed higher rates of elevated PSA (>4.0 ng/ml) (64% vs 38%) and chronic prostatic inflammation (56% vs 37%) compared to those without AUR.
- Prostatic inflammation was associated with significantly higher mean PSA levels in the AUR group and independently contributed to AUR.
- The odds ratio for AUR in patients with chronic inflammation and elevated PSA was 4.14.
Conclusions:
- Chronic prostatic inflammation is associated with elevated PSA levels and acute urinary retention (AUR).
- Histopathological evidence suggests chronic inflammation may play a significant role in the pathophysiology of AUR.
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