Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Steap proteins are metalloreductases.

Robert S Ohgami1, Dean R Campagna, Alice McDonald

  • 1Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Blood
|April 13, 2006
PubMed
Summary

Three Steap proteins (Steap2, Steap3, and Steap4) function as both iron and copper reductases, enhancing cellular metal uptake. These findings highlight their crucial role in regulating essential metal homeostasis in vivo.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digital and Manual Assessment of Intrafollicular Ki-67, <i>MYC</i>, and p53 in Classic Follicular Lymphoma.

Diagnostics (Basel, Switzerland)·2026
Same author

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same author

Study of inborn errors of immunity associated lymphoid proliferations identifies association of presence of somatic variations with large cell morphology, copy number alterations in TNFAIP3 and heterozygous variants in EMSY.

Virchows Archiv : an international journal of pathology·2026
Same author

Recurrent SWI/SNF Deficiency Defines a Subset of Peripheral T-Cell Lymphoma With Distinct Clinicopathologic Features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

Molecular Pathology, Artificial Intelligence, and New Technologies in Hematologic Diagnostics: Translational Opportunities and Practical Considerations.

Diagnostics (Basel, Switzerland)·2026
Same author

A single-center retrospective review of food retention during upper endoscopy following GLP-1 receptor agonist usage and introduction of the Tampa Intraluminal Gastric Residue (TiGR) grading scale.

Surgical endoscopy·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Iron and copper are vital essential metals for numerous enzymes in all organisms.
  • Transmembrane transport of iron and copper in eukaryotes involves a regulated single electron reduction process.
  • The mammalian ferrireductase, Steap3, was previously identified as critical for erythroid iron homeostasis.

Purpose of the Study:

  • To characterize all four members of the Steap protein family.
  • To determine if Steap proteins function as reductases for both iron and copper.
  • To investigate the physiological relevance of Steap proteins in metal transport.

Main Methods:

  • Homology analysis across the Steap protein family.
  • Expression profiling of Steap proteins in various tissues.

Related Experiment Videos

  • Functional assays to assess ferrireductase and cupric reductase activity in vitro.
  • Subcellular localization studies.

    • Main Results:

    • All four Steap proteins were characterized.
    • Steap2, Steap3, and Steap4 were identified as both ferrireductases and cupric reductases.
    • These three Steap proteins were shown to stimulate cellular uptake of iron and copper in vitro.
    • Tissue expression patterns and subcellular localization suggest in vivo physiological roles.

    Conclusions:

    • Steap2, Steap3, and Steap4 are multifunctional reductases for both iron and copper.
    • These proteins play a significant role in regulating cellular iron and copper uptake.
    • The study identifies Steap proteins as key players in systemic metal ion homeostasis.