Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis.

eLife·2026
Same author

Cytopenias and Functional Defects in a Novel Murine Model of VPS45 Severe Congenital Neutropenia.

bioRxiv : the preprint server for biology·2026
Same author

Plasticity under pressure: biology and detection of lineage switch in acute leukemia.

Leukemia·2026
Same author

Splenosis of the liver: a unique clinicopathologic challenge.

Journal of hematopathology·2026
Same author

Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

Journal of clinical pathology·2026
Same author

Flow cytometric quantitation of CD34+ progenitors in peripheral blood: an adjunct tool for diagnostic evaluation of pancytopenia.

American journal of clinical pathology·2026

Related Experiment Video

Updated: May 22, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Recurrent SWI/SNF Deficiency Defines a Subset of Peripheral T-Cell Lymphoma With Distinct Clinicopathologic Features.

Jacob R Bledsoe1, Judith A Ferry2, Jingwei Li3

  • 1Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Pediatric Peripheral T-cell Lymphoma (PTCL, NOS) with SWI/SNF-deficiency shows distinct molecular and clinicopathologic features. This rare T-cell lymphoma subtype presents unique characteristics compared to SWI/SNF-intact PTCL, NOS in young patients.

Keywords:
INI1SMARCB1SMARCE1childhoodlymphomapediatric

More Related Videos

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Related Experiment Videos

Last Updated: May 22, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is rare in pediatric and young adult populations.
  • Limited data exists on the clinicopathologic and molecular characteristics of PTCL, NOS in patients ≤21 years old.

Purpose of the Study:

  • To characterize the clinicopathologic and molecular features of PTCL, NOS in pediatric and young adult patients.
  • To investigate the role of SWI/SNF pathway alterations in PTCL, NOS in this age group.

Main Methods:

  • Characterization of 16 PTCL, NOS cases in patients ≤21 years old.
  • Immunohistochemistry and next-generation sequencing for SMARCB1/INI1 and SMARCE1 alterations.
  • Analysis of SWI/SNF-intact group for TET2, PTEN, EZH2, TP53, CDKN2A, and 22q11.2 alterations.
  • Assessment of cytomorphology, cell surface markers (CD45, CD43, CD3, pan-T-cell antigens), and clinical outcomes (OS, EFS).

Main Results:

  • Seven cases (44%) showed SMARCB1/INI1 loss or alterations; one case had SMARCE1 alterations.
  • SWI/SNF-deficient PTCL, NOS exhibited intermediate-to-large cell morphology, high mitotic and apoptotic activity, Reed-Sternberg-like cells, necrosis, and fibrosis.
  • Distinct immunophenotypes were observed: SWI/SNF-deficient cases were predominantly CD4+/CD8-, TCRab, PTCL-GATA3, while SWI/SNF-intact cases were CD8+/CD4-, TCRgd, PTCL-TBX21.
  • Decreased/absent CD3 expression and loss of pan-T-cell antigens were more frequent in SWI/SNF-deficient cases.
  • While treatment was heterogeneous, SWI/SNF-deficient cases showed trends towards longer overall survival (OS) and event-free survival (EFS) compared to SWI/SNF-intact cases, though not statistically significant.

Conclusions:

  • SWI/SNF-deficient PTCL, NOS represents a biologically distinct subtype in pediatric and young adult patients.
  • This subtype is associated with characteristic clinicopathologic features and molecular alterations.
  • Further research is warranted to understand the specific therapeutic strategies for SWI/SNF-deficient PTCL, NOS.