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Updated: Aug 9, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Cyanide ion cocatalysis in Ti(salen) catalysed asymmetric cyanohydrin carbonate synthesis
Yuri N Belokon1, Eisuke Ishibashi, Hiroshi Nomura
1A. N. Nesmeyanov Institute of Organo-Element Compounds, Russian Academy of Sciences, Vavilov 28, Russian Federation.
Abstract:
In the presence of potassium cyanide or the potassium cyanide/18-crown-6 complex as a cocatalyst, 1-2 mol% of titanium(salen) complex catalyses the asymmetric addition of achiral cyanoformates to aldehydes, giving cyanohydrin carbonates with high enantiomeric excesses; and catalyses the diastereoselective addition of chiral cyanoformates derived from alpha-methylbenzyl alcohol to aldehydes, a reaction which exhibits double asymmetric induction.
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