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Uremia associated with erythrophagocytosis by small intestine epithelial cells: a case report
Juliana Fariña1, M Concepción Millana, Maria Jesús Fernández-Aceñero
1Departments of Pathology, Hospital Clínico San Carlos, Madrid, Spain.
Background:
Anemia is a frequent finding in patients with uremia due to chronic renal failure. Two factors contribute to the decrease in the red blood cell count and worsen the patient's general status: depression of erythropoiesis and shortening of the red blood cell lifespan.
Case:
A novel response mechanism to erythrocyte loss took place in a uremic patient with gastrointestinal hemorrhage. In an autopsy case of an 80-year-old woman dying of uremia, analysis of an intestinal fluid smear revealed small intestine epithelial cells engulfing complete erythrocytes.
Conclusion:
This cytologic finding could account for a potential response mechanism to counteract the massive erythrocyte loss that occurs in hemorrhagic anemia with a uremic background.
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