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[Hypercalcemic crisis associated with primary hyperparathyroidism during pregnancy].

Miguel R Branco1, Carla T Rodrigues, António Campos

  • 1Unidade de Diagnóstico Pré-Natal/Medicina Fetal, Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, Coimbra.

Acta Medica Portuguesa
|April 14, 2006
PubMed
Summary

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Primary hyperparathyroidism during pregnancy is rare but risky. Surgical removal of parathyroid hyperplasia resolved hypercalcemia and symptoms, leading to a healthy infant delivery.

Area of Science:

  • Endocrinology
  • Obstetrics
  • Surgical Case Report

Background:

  • Primary hyperparathyroidism (PHP) in pregnancy is uncommon, posing risks to both mother and fetus due to hypercalcemia.
  • Maternal hypercalcemia can lead to complications such as nausea, vomiting, cognitive dysfunction, and hypertension.
  • Fetal risks include intrauterine growth restriction and potential neonatal complications.

Observation:

  • A 41-year-old pregnant woman (gravida 2, para 1) at 22 weeks gestation presented with hypercalcemic crisis.
  • Symptoms included nausea, vomiting, and mild cognitive dysfunction.
  • Laboratory findings indicated hypercalcemia linked to parathyroid hyperplasia.

Findings:

  • Surgical removal of the hyperplastic parathyroid glands resulted in complete resolution of maternal hypercalcemia and symptoms.

Related Experiment Videos

  • The pregnancy was managed and complicated by transient hypertension.
  • A healthy male infant, small for gestational age, was delivered at term without neonatal complications related to PHP.

    • Implications:

    • This case highlights the successful surgical management of primary hyperparathyroidism during pregnancy.
    • Prompt diagnosis and intervention can mitigate risks associated with hypercalcemia in pregnant patients.
    • Effective management ensures favorable maternal and fetal outcomes, even in rare endocrine complications during gestation.