Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular contributions to glomerular size-selectivity.

W M Deen1

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA. wmdeen@mit.edu

Kidney International
|April 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Course of preeclamptic glomerular injury after delivery.

American journal of physiology. Renal physiology·2008
Same author

The dynamics of glomerular filtration in the puerperium.

American journal of physiology. Renal physiology·2003
Same author

Effects of plasma proteins on sieving of tracer macromolecules in glomerular basement membrane.

American journal of physiology. Renal physiology·2001
Same author

Spatial range of autocrine signaling: modeling and computational analysis.

Biophysical journal·2001
Same author

Structural determinants of glomerular permeability.

American journal of physiology. Renal physiology·2001
Same author

Analysis of the effects of cell spacing and liquid depth on nitric oxide and its oxidation products in cell cultures.

Chemical research in toxicology·2001
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-Storing Histiocytosis Causing Severe AKI.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
Same journal

Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

Kidney international·2026
See all related articles

The glomerular filtration barrier restricts large proteins but allows small solutes to pass. New findings suggest glomerular filtration rate influences this size-selectivity, impacting protein restriction.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Glomerular Filtration

Background:

  • The glomerular capillary wall exhibits size-selectivity, freely filtering small solutes while restricting large proteins.
  • The relative contributions of the endothelium and epithelium to this size-selectivity remain unclear.

Discussion:

  • The study by Rippe et al. investigated the relationship between the sieving coefficient of Ficoll and glomerular filtration rate.
  • This inverse relationship provides novel insights into the mechanisms of glomerular size-selectivity.

Key Insights:

  • Glomerular filtration rate (GFR) plays a crucial role in determining the kidney's ability to restrict large molecules.
  • The findings challenge previous assumptions about the fixed nature of glomerular size-selectivity.

Related Experiment Videos

Outlook:

  • Further research is needed to elucidate the precise cellular and molecular mechanisms underlying GFR-dependent size-selectivity.
  • Understanding these mechanisms could lead to new therapeutic strategies for proteinuric kidney diseases.