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Tinnitus treatment with acamprosate: double-blind study.
Andréia A Azevedo1, Ricardo R Figueiredo
1OTOSUL, Otorrinolaringologia Sul-Fluminense, Hospital São Camilo, Volta Redonda, RJ. otosul@uol.com.br
Brazilian Journal of Otorhinolaryngology
|April 14, 2006
Summary
Acamprosate, an alcoholism treatment, shows significant success in relieving sensorineural tinnitus. This study found it to be a safe and effective therapeutic option for tinnitus patients.
Area of Science:
- Otolaryngology
- Neuroscience
- Pharmacology
Background:
- Tinnitus treatment remains a significant challenge for otolaryngologists due to unknown pathophysiology.
- Current therapies yield variable results, highlighting the need for novel approaches.
Purpose of the Study:
- To assess the efficacy and safety of acamprosate for treating sensorineural tinnitus.
- Acamprosate, known for its effects on glutamatergic and GABA neurotransmission, has not been previously studied for tinnitus.
Main Methods:
- A prospective, double-blind, randomized clinical trial was conducted.
- Fifty patients with sensorineural tinnitus were divided into two groups: 25 received acamprosate and 25 received a placebo for 3 months.
- Efficacy and safety were evaluated using a subjective 1-10 scoring system provided by patients.
Main Results:
- A high success rate of 86.9% was observed in tinnitus relief.
- Over 50% relief was achieved in 47.8% of cases.
- The incidence of side effects was low (12%) and all were mild.
Conclusions:
- Acamprosate presents a safe and effective alternative for sensorineural tinnitus treatment.
- The drug's mechanism, involving neurotransmitter regulation, appears beneficial for tinnitus symptoms.