Related Experiment Video

Updated: Aug 9, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

[Treatment of neonatal respiratory distress syndrome with surfactant BL]

G N Zatovka, S A Duginova, A A Safarov

    Anesteziologiia I Reanimatologiia
    |April 15, 2006
    PubMed

    Insights

    The Russian drug Surfactant BL significantly improved blood oxygenation and artificial ventilation in premature newborns with respiratory distress syndrome (RDS). This treatment offers a statistically significant advantage for positive treatment outcomes in intensive care.

    Area of Science:

    • Neonatology
    • Pediatric Intensive Care
    • Pulmonology

    Background:

    • Respiratory distress syndrome (RDS) is a critical condition in premature newborns.
    • Effective management of RDS is crucial for improving survival rates and long-term outcomes.
    • Current intensive care strategies require continuous evaluation for optimal patient care.

    Purpose of the Study:

    • To evaluate the efficacy of the Russian drug Surfactant BL in the complex intensive care of premature newborns with RDS.
    • To compare the outcomes of treatment with Surfactant BL against standard therapy in a control group.
    • To analyze the impact of Surfactant BL on blood oxygenation and artificial ventilation parameters.

    Main Methods:

    • A study group of 45 premature newborns with RDS received Surfactant BL as part of intensive care.
    • A control group of 52 newborns with RDS received standard therapy prior to Surfactant BL implementation.
    • Statistical analysis was performed to ensure group uniformity and compare treatment outcomes, focusing on blood oxygenation and artificial ventilation parameters.

    Main Results:

    • Surfactant BL treatment led to more rapid improvements in blood oxygenation parameters (pO2, A-aDO2, respiratory coefficient).
    • Oxygenation parameters remained significantly better in the Surfactant BL group throughout the intensive care period.
    • Artificial ventilation (AV) parameters, including FiO2, were reduced more quickly and to a greater extent in the Surfactant BL group.

    Conclusions:

    • Surfactant BL demonstrates a statistically significant advantage in achieving positive treatment outcomes for neonatal infants with RDS.
    • The drug facilitates faster recovery of blood oxygenation and allows for quicker weaning from mechanical ventilation.
    • Surfactant BL is a valuable therapeutic agent for complex intensive care of premature newborns suffering from respiratory distress syndrome.

    More Related Videos

    Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)06:22

    Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

    Published on: April 7, 2021

    Related Concept Videos

    Breathing01:05

    Breathing

    The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
    Acute Respiratory Failure-V01:29

    Acute Respiratory Failure-V

    The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
    Ensure that patients are monitored continuously for their response to therapy, including changes in...
    Pulmonary Cycle: Exhalation01:17

    Pulmonary Cycle: Exhalation

    In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
    Flail Chest-II01:26

    Flail Chest-II

    Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
    Assessment:
    1. Clinical Evaluation:
    History:
    Acute Respiratory Failure-III01:30

    Acute Respiratory Failure-III

    Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
    Mechanical Ventilation III: Noninvasive Ventilation01:23

    Mechanical Ventilation III: Noninvasive Ventilation

    Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
    Noninvasive Positive-Pressure Ventilation (NIPPV)