Blood mononuclear cells energy metabolism response to muscular exercise

In a study of 4 enzymatic activities in human blood mononuclear cells before and immediately after standard maximal exercise test (25 min) on treadmill we noted: (1) a significant decrease in the activity of the pyruvate dehydrogenase complex (PDHc); (2) a significant increase in the activity of the citrate synthase (CS); and (3) no significant changes in the activities of cytochrome c oxydase and succinate cytochrome reductase. Although non-specifically stimulated (antigen or even mitogen), the blood mononuclear cells responded metabolically to muscular exercise. Pyruvate dehydrogenase (PDHc) activity of blood mononuclear cells appeared to decrease via enzyme interconversion regulation of PDHc. It is not known if these changes can be linked to the studies indicated altered immune function after a single bout of exercise.